SPSS 25.0 statistical software package (SPSS Inc. Chicago, IL, USA) was used for statistical analyses, which was validated by Prism 8.0 (GraphPad Software). A Chi-square test was used to compare in ratios between the two groups. Continuous data were shown as the mean ± SD64 (link) for normally distributed data. Due to the skewed distribution of TG, median and quartile spacing were used to compare the differences. Mann-Whitney nonparametric tests and analysis of covariance (ANCOVA) were performed for comparing continuous data65 (link). ANCOVA is an ideal statistical method for studying the interaction between genes and the environment. It is characterized by the ability to correct for confounding factors66 (link),67 (link). R software (version 3.5.0) was used for further bioinformatic analyses. The receiver operating characteristic (ROC) curve was used to evaluate the diagnostic sensitivity of plasma miRNAs and circRNAs in patients with CAD. The areas under the curves (AUC) were calculated and compared. All tests were conducted as two-sided and statistical significance was defined as P < 0.05.
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