Genetic Variants and Brain Tumor Risk

SNPs that were significantly (P < 1×10^-5) associated with the different types of malignant brain tumors were selected as IVs. Since the number of independent SNPs of malignant brain tumors was limited, we selected eligible SNPs by relaxing the GWAS P threshold to 1×10^-5 when it was treated as exposure. Independent variables from each other were retained based on European ancestry reference data from the 1000 Genomes Project (linkage disequilibrium (LD), r² < 0.001). As above, we also used the PhenoScanner tool to manually remove SNPs and their proxies (r² > 0.80) that were significantly (P <5×10^-8) associated with potential confounders of the VEGF-malignant relationship based on published studies: white cell (31 (link), 32 (link)). One SNP (rs147958197) for malignant brain tumors was associated with monocyte count, monocyte percentage of white cells or granulocyte percentage of myeloid white cells.

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Zhang Q., Wu G., Zhang X., Zhang J., Jiang M., Zhang Y., Ding L, & Wang Y. (2023). Vascular endothelial growth factor and risk of malignant brain tumor: A genetic correlation and two-sample Mendelian randomization study. Frontiers in Oncology, 13, 991825.

Publication 2023

European Genomes Granulocyte Gwas Malignant brain tumors Malignant tumors of the brain Monocyte Myeloid cells Vegf White cells

Corresponding Organization : Beijing Shijitan Hospital

Other organizations : Beijing Sanbo Brain Hospital

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Variable analysis

independent variables

SNPs that were significantly (P < 1×10^-5) associated with the different types of malignant brain tumors

dependent variables

Types of malignant brain tumors

control variables

Potential confounders of the VEGF-malignant relationship based on published studies: white cell (31, 32).
One SNP (rs147958197) for malignant brain tumors was associated with monocyte count, monocyte percentage of white cells or granulocyte percentage of myeloid white cells.

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