Dynamic 11C-PiB PET scans were obtained on 3D mode from a GE Advance scanner, started immediately after intravenous bolus injection of 11C-PiB. Distribution volume ratio (DVR) images were computed using a simplified reference tissue model [34 (link)] with cerebellar gray matter as the reference region. Mean cortical amyloid-β (Aβ) burden was calculated as the average of the DVR values in anterior, middle, and posterior cingulate regions, superior, middle and inferior frontal and orbitofrontal, superior parietal, supramarginal and angular gyrus regions, superior, middle and inferior temporal, pre-cuneus, superior, middle and inferior occipital, excluding the sensorimotor strip. All analyses were run using PiB cortical DVR (cDVR) both as a continuous variable and a dichotomized variable based on PiB positivity (defined as cDVR > 1.061 based on 2-class Gaussian mixture modeling [35 (link)]).
Protocol detail
Dynamic 11C-PiB PET Imaging for Amyloid-β Burden
Partial Protocol Preview
This section provides a glimpse into the protocol.
The remaining content is hidden due to licensing restrictions, but the full text is available at the following link:
Access Free Full Text.
11c pib
Amyloid
Angular gyrus
Cerebellar gray matter
Cortical
Cuneus
Pet scans
Posterior cingulate regions
Tissue
Corresponding Organization : Johns Hopkins University
Top 5 similar protocols
Variable analysis
independent variables
- PiB cortical DVR (cDVR)
- Mean cortical amyloid-β (Aβ) burden
- Cerebellar gray matter as the reference region
- The analyses were run using PiB cortical DVR (cDVR) both as a continuous variable and a dichotomized variable based on PiB positivity (defined as cDVR > 1.061 based on 2-class Gaussian mixture modeling)
Annotations
Based on most similar protocols
Etiam vel ipsum. Morbi facilisis vestibulum nisl. Praesent cursus laoreet felis. Integer adipiscing pretium orci. Nulla facilisi. Quisque posuere bibendum purus. Nulla quam mauris, cursus eget, convallis ac, molestie non, enim. Aliquam congue. Quisque sagittis nonummy sapien. Proin molestie sem vitae urna. Maecenas lorem.
Sign up for free or login to display all annotations
As authors may omit details in methods from publication, our AI will look for missing critical information across the 5 most similar protocols.
About PubCompare
Our mission is to provide scientists with the largest repository of trustworthy protocols and intelligent analytical tools, thereby offering them extensive information to design robust protocols aimed at minimizing the risk of failures.
We believe that the most crucial aspect is to grant scientists access to a wide range of reliable sources and new useful tools that surpass human capabilities.
However, we trust in allowing scientists to determine how to construct their own protocols based on this information, as they are the experts in their field.
Ready to get started?
Sign up for free.
Registration takes 20 seconds.
Available from any computer
No download required
Revolutionizing how scientists
search and build protocols!