Neuro-Ophthalmological Evaluation of Study Participants
In parallel to the cognitive assessment, study participants underwent a complete neuro-ophthalmological evaluation, which lasted about 20 min and was performed by an optometrist. The evaluation comprised: (1) a review of past ophthalmological diseases, treatments and surgeries, (2) monocular visual acuity assessment with the participants wearing their habitual correction for refractive error using a pinhole occluder and the Early Treatment of Diabetic Retinopathy Study (ETDRS) chart (Chew et al., 2009 (link); Bokinni et al., 2015 (link)), (3) intraocular pressure (IOP) measurement by Icare tonometry (Pakrou et al., 2008 (link)), and (4) swept source (SS) OCT scan. More details can be found elsewhere (Marquié et al., 2022 (link)). The ophthalmologist and neurologists were blind to each other’s diagnosis.
Marquié M., García-Sánchez A., Alarcón-Martín E., Martínez J., Castilla-Martí M., Castilla-Martí L., Orellana A., Montrreal L., de Rojas I., García-González P., Puerta R., Olivé C., Cano A., Hernández I., Rosende-Roca M., Vargas L., Tartari J.P., Esteban-De Antonio E., Bojaryn U., Ricciardi M., Ariton D.M., Pytel V., Alegret M., Ortega G., Espinosa A., Pérez-Cordón A., Sanabria Á., Muñoz N., Lleonart N., Aguilera N., Tárraga L., Valero S., Ruiz A, & Boada M. (2023). Macular vessel density in the superficial plexus is not associated to cerebrospinal fluid core biomarkers for Alzheimer’s disease in individuals with mild cognitive impairment: The NORFACE cohort. Frontiers in Neuroscience, 17, 1076177.
Participants wearing their habitual correction for refractive error
Use of pinhole occluder during visual acuity assessment
Use of Early Treatment of Diabetic Retinopathy Study (ETDRS) chart for visual acuity assessment
Use of Icare tonometry for IOP measurement
Ophthalmologist and neurologists were blind to each other's diagnosis
positive controls
None explicitly mentioned
negative controls
None explicitly mentioned
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