Seroprevalence of Borrelia burgdorferi in France

The original study was designed to investigate the seroprevalence of Borrelia burgdorferi sl. The sample size for our study was therefore determined to answer this research objective. The number of required subjects was calculated for each of the following five geographic areas: northwestern France including Normandie (Haute-Normandie and Basse-Normandie), Bretagne and Pays-de-la-Loire regions; north central France including Hauts-de-France (Picardie, Nord-Pas-de-Calais), Île-de-France, and Centre regions; northeastern France including Alsace, Lorraine, Champagne-Ardenne, Bourgogne, and Franche-Comté regions; and Auvergne and Limousin regions, both located in the center of France. Assuming a B. burgdorferi sl seroprevalence of 5% in northwestern and north central France and of 15% in northeastern France [20 (link),21 (link),22 (link)], a sample of 2591 individuals would be required to achieve a minimum precision of 1.5% and a maximum precision of 4% in the estimation of B. burgdorferi sl seroprevalence. A total of 1778 forestry workers were included from May 2019 to March 2020. The number of participants was lower than required due to the COVID-19 pandemic as the lockdown led to the interruption of data collection. We conducted power calculations to estimate the precision of hantavirus seroprevalence estimation using the available sample (see Table S1).

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Krug C., Rigaud E., Siby-Diakite D., Bénézet L., Papadopoulos P., de Valk H., Deffontaines G., Septfons A, & Reynes J.M. (2023). Seroprevalence of Hantavirus in Forestry Workers, Northern France, 2019–2020. Viruses, 15(2), 338.

Publication 2023

Borrelia burgdorferi Covid 19 pandemic Hantavirus Workers

Corresponding Organization : Université Paris Cité

Other organizations : European Centre for Disease Prevention and Control, Santé Publique France, Clinique Mutualiste de l'Estuaire

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Variable analysis

independent variables

Geographic area (northwestern France including Normandie, Bretagne and Pays-de-la-Loire regions; north central France including Hauts-de-France, Île-de-France, and Centre regions; northeastern France including Alsace, Lorraine, Champagne-Ardenne, Bourgogne, and Franche-Comté regions; and Auvergne and Limousin regions)

dependent variables

Seroprevalence of Borrelia burgdorferi sl

control variables

Assumed Borrelia burgdorferi sl seroprevalence in different geographic areas (5% in northwestern and north central France, 15% in northeastern France)

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