Stereotactic Radiosurgery for Brain Metastases

SRS was performed on the Leksell Gamma Knife Model C (Elekta, Stockholm, Sweden) prior to May 2009, and Perfexion after May 2009. Same day headframe fixation was used for immobilization. Patients underwent a contrast-enhanced stereotactic magnetic resonance imaging scan of the brain with headframe in place. The GammaPlan Treatment Planning System (AB Elekta, Stockholm, Sweden) was used to develop the treatment plan. Median marginal dose prescribed was 18–22 Gy and was generally prescribed to the 50% isodose line. The dose selected was based on guidelines previously described by Shaw et al.^{19 (link)}. The targeting of the resection cavity of the metastasis was previously described by Jensen et al.^{20 (link)}.

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Soike M.H., Logue J., Qasem S., Hughes R.T., McTyre E., Su J., Triozzi P., Bendandi M., Lo H.W., Ahmed T., O’Neill S.S., Debinski W., Pasche B., Watabe K., Miller L.D., Chan M.D, & Ruiz J. (2019). CD138 plasma cells may predict brain metastasis recurrence following resection and stereotactic radiosurgery. Scientific Reports, 9, 14385.

Publication 2019

Leksell Gamma Knife Model C

Brain Cavity Gamma knife Immobilization Magnetic resonance imaging scan Metastasis Patients

Corresponding Organization : University of Alabama at Birmingham

Other organizations : Moffitt Cancer Center, University of South Florida, University of Kentucky, Wake Forest University, Prisma Health, W. G. (Bill) Hefner VA Medical Center

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Variable analysis

independent variables

Leksell Gamma Knife Model C used prior to May 2009
Leksell Gamma Knife Perfexion used after May 2009

dependent variables

Median marginal dose prescribed (18–22 Gy)
Dose prescribed to the 50% isodose line

control variables

Same day headframe fixation used for immobilization
Contrast-enhanced stereotactic magnetic resonance imaging scan of the brain with headframe in place
GammaPlan Treatment Planning System (AB Elekta, Stockholm, Sweden) used to develop the treatment plan
Targeting of the resection cavity of the metastasis

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