Mst1 downregulation was responsible for shikonin-mediated activation on Nrf2. (
Shikonin Activates Nrf2 via Mst1 Downregulation
Corresponding Organization : Renmin Hospital of Wuhan University
Variable analysis
- Shikonin administration
- Overexpression of Mst1
- Expression of Nrf2
- ROS level
- Cell viability
- Control groups
- Positive control: Cells infected with GFP, where shikonin could reverse the low expression of Nrf2 induced by DOX.
- Negative control: Cells overexpressing Mst1, where shikonin had no effect on the low expression of Nrf2 induced by DOX.
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