From February 2008 through December 2009, we enrolled 1208 patients at 44 clinical centers in the United States. Eligibility criteria included an age of 50 years or more, the presence in the study eye (one eye per patient) of previously untreated active choroidal neovascularization due to AMD, and visual acuity between 20/25 and 20/320 on electronic visual-acuity testing.8 (link) To establish the presence of active choroidal neovascularization, we required the presence of leakage, as seen on fluorescein angiography, and of fluid, as seen on time-domain optical coherence tomography (OCT), located either within or below the retina or below the retinal pigment epithelium. Inclusion criteria were neovascularization, fluid, or hemorrhage under the fovea. The study was approved by the institutional review board at each clinical center. All patients provided written informed consent.