Rota-rod Assessment of Opioid Motor Impairment

We used the rota-rod test to assess the well-known motor impairment side effects of opioids. Rats were acclimatized and trained on a rotating rod (Ugo Basile, Italy) that accelerated from 0 to 30 rpm in 180 seconds. On the day of testing, rat performance on the rod was measured before (pre-drug baseline) and 45 minutes after administration of DALDA or morphine. The time (in seconds) that each animal remained on the accelerating rod without falling was recorded.^{19 (link),24 (link)}

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Tiwari V., Yang F., He S.Q., Shechter R., Zhang C., Shu B., Zhang T., Tiwari V., Wang Y., Dong X., Guan Y, & Raja S.N. (2016). Activation of Peripheral Mu-Opioid Receptors by Dermorphin [D-Arg2, Lys4] (1-4) amide Leads to Modality-preferred Inhibition of Neuropathic Pain. Anesthesiology, 124(3), 706-720.

Publication 2015

rotating rod

Animal Dalda Drug Morphine Opioids Seconds

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Protocol cited in 2 other protocols

Variable analysis

independent variables

Administration of DALDA or morphine

dependent variables

Time (in seconds) that each animal remained on the accelerating rod without falling

control variables

Rat performance on the accelerating rod before drug administration (pre-drug baseline)

controls

Positive control: Not specified
Negative control: Not specified

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