This is a population-based study that will enroll all eligible adult patients served by clinicians in the Division of Medical Oncology at MCR and in hematology-oncology services at MCHS sites. This inclusive enrollment approach substantially increases the generalizability and external validity of our real-world pragmatic trial. Specifically, the E2C2 pragmatic trial will include all adult patients being treated or monitored for cancer or receiving survivorship care for cancer at the MCR medical oncology practice and the MCHS hematology-oncology practices. MCR patients in this trial will have solid tumors, and MCHS patients may have solid or liquid tumors. Data will not be used from patients who have indicated that they do not want their EHR data used for research according to the Minnesota Health Records Act [59 ].
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