Protocol detail

Renal Denervation in Chronic Kidney Disease

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In these sheep, arterial pressure and kidney function were assessed at 6 months of age to establish baseline and these data have been previously reported^{71 (link)}. At 10 months of age, animals were randomly assigned to receive either RDN procedure (six, two-minute radiofrequency ablations per artery) or sham-procedure using the Symplicity Flex catheter (Symplicity, Medtronic Ardian Inc, CA) as previously described^{29 (link)}. This resulted in four groups; control-RDN; N = 7, CKD-RDN; N = 7, control-intact; N = 6 and CKD-intact; N = 7.

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Singh R.R., McArdle Z., Singh H., Booth L.C., May C.N., Head G.A., Moritz K.M., Schlaich M.P, & Denton K.M. (2021). Blunted natriuretic response to saline loading in sheep with hypertensive kidney disease following radiofrequency catheter-based renal denervation. Scientific Reports, 11, 14795.

Publication 2021

Symplicity Flex

Animals Artery Catheter Kidney Radiofrequency ablations Sheep

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Variable analysis

independent variables

RDN procedure (six, two-minute radiofrequency ablations per artery)
Sham-procedure using the Symplicity Flex catheter

dependent variables

Arterial pressure
Kidney function

control variables

Baseline arterial pressure and kidney function assessed at 6 months of age

controls

Positive control: Control-RDN group (N = 7)
Negative control: Control-intact group (N = 6)

Annotations

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