Intermittent Theta Burst Stimulation for Parkinson's

Figure 1 shows the timeline of the experiments. Four weeks after 6-OHDA injection, the lesioned rats which passed the apomorphine-induced contralateral rotation test were divided into three groups according to the number of pulses received: sham-iTBS, 1 block-iTBS (one iTBS block) and 3 block-iTBS (three blocks of iTBS). All three groups were subjected to behavioral tests, histology and immunohistochemistry at 30 or 80 min post-stimulation. In the specific case of behavioral tests including the object-place recognition (OPR) and hole-board (HB) test, the first trial of the two tests started at 30 or 80 min after real (different blocks) or sham-iTBS. Besides, hippocampal local field potential (LFP) was recorded in all three groups for 3 h, including 1 h pre-stimulation baseline and 2 h post-stimulation recordings 4 weeks after 6-OHDA injection.

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Wang Y., Liu J., Hui Y., Wu Z., Wang L., Wu X., Bai Y., Zhang Q, & Li L. (2023). Dose and time-dependence of acute intermittent theta-burst stimulation on hippocampus-dependent memory in parkinsonian rats. Frontiers in Neuroscience, 17, 1124819.

Publication 2023

Apomorphine Behavioral tests Immunohistochemistry Pulses Rats Timeline

Corresponding Organization : Second Affiliated Hospital of Xi'an Jiaotong University

Other organizations : Xi'an Jiaotong University

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Variable analysis

independent variables

Number of pulses received (sham-iTBS, 1 block-iTBS, 3 block-iTBS)

dependent variables

Behavioral tests (object-place recognition, hole-board)
Histology
Immunohistochemistry
Hippocampal local field potential (LFP) recordings

control variables

Time of behavioral tests (30 min or 80 min post-stimulation)
Time of recordings (1 h pre-stimulation baseline, 2 h post-stimulation)

controls

Sham-iTBS group

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