Hyperpigmentation targets were retrieved from GeneCards (version 3.0; https://www.genecards.org/) (Safran et al. 2010) (link) and DisGeNET (version 7.0, http://www.disgenet.org/) (Pinero et al. 2020) databases using the keyword 'hyperpigmentation' . The species was limited to Homo sapiens. The duplicate targets were eliminated, and the names were standardized using the UniProt database.