In a round‐bottomed flask equipped with a reflux condenser, a solution of trans‐chalcone (50 mg, 4.8 mm) and nitromethane (5 equiv, 24 mm) was stirred in either methanol, ethanol, 2propanol, ethyl acetate, acetone, or acetonitrile solvents (50 mL). In the case of nitromethane as both solvent and reagent, trans‐chalcone (50 mg, 4.8 mm) was directly dissolved in nitromethane (50 mL). To these solutions Amberlyst A21 or Amberlite IRA67 (50 mg) catalyst was added. After stirring the reaction mixture at 30–70 °C temperature for 24 h, conversions were determined by HPLC.
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