Healthy Pregnancy Cohort Study

Participants without known health, environmental, and/or socioeconomic constraints were invited to participate in the study. Further inclusion criteria were used: living at an altitude lower than 1,500 m and near the study area (intended to promote compliance for the duration of the study and any possible follow-up studies); age ≥ 18 y and ≤ 40 y; body mass index (BMI) 18–30 kg/m²; singleton pregnancy; gestational age at entry between gestational week 8+0 d and 12+6 d according to reliable information on last menstrual period (LMP) and confirmed by ultrasound measurement of fetal crown–rump length; no history of chronic health problems; no long-term medication (including fertility treatment); no environmental or economic constraints likely to impede fetal growth; not smoking currently or in the previous 6 mo; no history of recurrent miscarriages; no previous preterm delivery (<37 wk) or birthweight < 2,500 g; and no evidence in the present pregnancy of congenital disease or fetal anomaly at study entry. Fetal anomalies detected during pregnancy or at birth were noted and verified postnatally. Pregnancies in which small-for-gestation-age fetuses were observed or intrauterine growth restriction was suspected were also noted. All mothers recruited were followed up until the end of the study, apart from those withdrawing consent.

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Kiserud T., Piaggio G., Carroli G., Widmer M., Carvalho J., Neerup Jensen L., Giordano D., Cecatti J.G., Abdel Aleem H., Talegawkar S.A., Benachi A., Diemert A., Tshefu Kitoto A., Thinkhamrop J., Lumbiganon P., Tabor A., Kriplani A., Gonzalez Perez R., Hecher K., Hanson M.A., Gülmezoglu A.M, & Platt L.D. (2017). The World Health Organization Fetal Growth Charts: A Multinational Longitudinal Study of Ultrasound Biometric Measurements and Estimated Fetal Weight. PLoS Medicine, 14(1), e1002220.

Publication 2017

Birth Birthweight Body mass index Congenital disease Fertility Fetal anomalies Fetal growth Fetal ultrasound Fetuses Gestational age Health participants Intrauterine growth restriction Medication Menstrual period Mothers Pregnancies Preterm delivery Recurrent miscarriages

Corresponding Organization : World Health Organization

Other organizations : Centro Rosarino de Estudios Perinatales, Rigshospitalet, Universidade Estadual de Campinas (UNICAMP), Assiut University, Milken Institute, George Washington University, Assistance Publique – Hôpitaux de Paris, Université Paris-Sud, Hôpital Antoine-Béclère, University Medical Center Hamburg-Eppendorf, Universität Hamburg, University of Kinshasa, Khon Kaen University, All India Institute of Medical Sciences, Pontificia Universidad Católica de Chile, University of Southampton, University of California, Los Angeles, American Institute of Ultrasound in Medicine

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Variable analysis

independent variables

Altitude (lower than 1,500 m)
Proximity to study area
Age (≥ 18 y and ≤ 40 y)
Body mass index (18–30 kg/m^2)
Singleton pregnancy
Gestational age at entry (between gestational week 8+0 d and 12+6 d)
Absence of chronic health problems
Absence of long-term medication (including fertility treatment)
Absence of environmental or economic constraints likely to impede fetal growth
Absence of smoking (currently or in the previous 6 mo)
Absence of recurrent miscarriages
Absence of previous preterm delivery (<37 wk) or birthweight < 2,500 g
Absence of congenital disease or fetal anomaly at study entry

dependent variables

Fetal growth and development
Pregnancy outcomes

control variables

Absence of congenital disease or fetal anomaly at study entry
Absence of environmental or economic constraints likely to impede fetal growth

positive controls

Not specified

negative controls

Not specified

Annotations

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