The transcriptome data were obtained from 514 patients with CRC (41 normal samples and 473 tumor samples) in the TCGA database (https://portal.gdc.cancer.gov/). The clinical data were from 452 groups of CRC patients, including survival time, age, sex, stage, TMN stage (Table 1). The known 259 ferroptosis genes (Driver: 108; Suppressor: 69; Marker: 111) were from the FerrDB database (http://www.zhounan.org/ferrdb/).