Primary Aldosteronism Investigation in Taiwan

The present study was based on the Taiwan Primary Aldosteronism Investigation (TAIPAI) database and tissue bank16 (link)17 (link)18 (link). The database was constructed from June 2008 to March 2011 for quality assurance at 2 medical centers and their 3 affiliated hospitals and two local hospitals in different cities in Taiwan19 (link). Before confirmatory tests, all antihypertensive medications were discontinued for at least 21 days. Diltiazem and/or doxazosin were administered to control markedly high blood pressure when required1 (link). Patients with an abnormal aldosterone-renin ratio (ARR) were confirmed with PA by saline infusion tests, and subsequently underwent imaging studies for subtype identification (figures S1 and S2).
PA confirmation and subtype studies were established in hypertensive patients according to the standard protocol of TAIPAI59 , including adrenal venous sampling and NP-59 scintigraphy with SPECT-CT imaging16 (link)17 (link)18 (link)20 (link) (see the supplementary file). Patients who were diagnosed with family type I (FH-I)/GRA were excluded via long-range polymerase chain reaction, as described previously21 (link).

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Wu V.C., Huang K.H., Peng K.Y., Tsai Y.C., Wu C.H., Wang S.M., Yang S.Y., Lin L.Y., Chang C.C., Lin Y.H., Lin S.L., Chu T.S, & Wu K.D. (2015). Prevalence and clinical correlates of somatic mutation in aldosterone producing adenoma-Taiwanese population. Scientific Reports, 5, 11396.

Publication 2015

Aldosterone Antihypertensive medications Ct scintigraphy Diltiazem Doxazosin High blood pressure Np 59 Patients Polymerase chain reaction Primary aldosteronism Renin Saline Scintigraphy Spect Spect ct Tissue Venous

Corresponding Organization :

Other organizations : National Taiwan University Hospital, Buddhist Tzu Chi General Hospital

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Variable analysis

independent variables

Discontinuation of antihypertensive medications for at least 21 days before confirmatory tests
Administration of diltiazem and/or doxazosin to control markedly high blood pressure when required

dependent variables

Abnormal aldosterone-renin ratio (ARR)
Primary aldosteronism (PA) confirmed by saline infusion tests
Subtype identification using imaging studies (adrenal venous sampling and NP-59 scintigraphy with SPECT-CT imaging)

control variables

Exclusion of patients diagnosed with family type I (FH-I)/GRA via long-range polymerase chain reaction

positive controls

Not specified

negative controls

Not specified

Annotations

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