The questionnaire was divided into two parts; one part was specifically reflecting e.g. demographics, morbidity, and pharmacological treatment while the other part concerned psychological distress, symptoms of anxiety and depression, measured with HADS.
The HADS aims to measure symptoms of anxiety and depression and consists of 14 items, seven items for the anxiety subscale (HADS Anxiety) and seven for the depression subscale (HADS Depression). HADS Anxiety focus mainly on symptoms of generalized anxiety disorder and HADS Depression is focused on anhedonia, the main symptom of depression [23 ]. Each item is scored on a response-scale with four alternatives ranging between 0 and 3. After adjusting for six items that are reversed scored, all responses are summed to obtain the two subscales. Recommended cut-off scores according to Zigmond & Snaith [5 (link)] are 8–10 for doubtful cases and ≥11 for definite cases. An optimal balance between sensitivity and specificity was found using a cut-off score of 8 or above for both HADS Anxiety and HADS Depression [6 (link)].
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