Estrogen Neuroprotection in Global Cerebral Ischemia
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Corresponding Organization :
Other organizations : Augusta University, North China University of Science and Technology, Institute of Molecular Medicine, Augusta University Health, Center for Neuroscience and Regenerative Medicine
Protocol cited in 6 other protocols
Variable analysis
- Ovariectomy status (bilateral ovariectomy or sham)
- Estradiol treatment (placebo or 17β-estradiol time-release pellets)
- Successful global cerebral ischemia (as indicated by loss of righting reflex and dilated, unresponsive pupils)
- Rectal temperature (maintained at 36.5 to 37.5°C)
- Anesthesia (chloral hydrate)
- Procedures for sham group (CCA exposure without occlusion)
- Positive control: Sham group, which underwent identical procedures except for the CCA occlusion
- Negative control: Not explicitly mentioned
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