Metabolic Factors in Type 2 Diabetes

A total of 95 volunteers were recruited from April 1, 2019 to June 30, 2022, including 36 females (17 T2DM patients, 19 normal controls) and 59 males (30 T2DM patients, 29 normal controls). T2DM Patients ranged from 32 to 71 years old (51.32 ± 10.60). The normal control group ranged from 31 to 68 years old (51.28 ± 8.91). Inclusion criteria: (1) patients diagnosed with T2DM and healthy volunteers with similar age to T2DM patients ( ± 3 years old) and no related diseases. Exclusion criteria: (1) patients unable to participate in MRI examination due to contraindications or other reasons; (2) patients with liver and pancreatic tumors; (3) patients after splenectomy; (4) patients with abnormal metabolic function or metabolic diseases excluding T2DM; (5) patients with hepatitis virus or hepatitis B, and liver iron deposition; (6) patients with liver trauma or patients receiving a liver transplant; (7) patients with pancreatic inflammation and alcoholics; (8) Patients with a history of drug therapy for the the pancreas (Sulfonamides, azathioprine, glucocorticoids, thiazide diuretics) and liver (Platinum agents, antibiotics, alkylating agents, antipsychotics, anti-tuberculosis drugs, and anti-tumor drugs) within six months. This study was conducted in accordance with the principles of the Declaration of Helsinki and approved by the hospital Ethics Committee (NO.2022-E460-01).

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Yi J., Xu F., Li T., Liang B., Li S., Feng Q, & Long L. (2023). Quantitative study of 3T MRI qDixon-WIP applied in pancreatic fat infiltration in patients with type 2 diabetes mellitus. Frontiers in Endocrinology, 14, 1140111.

Publication 2023

Alcoholics Alkylating agents Anti tuberculosis drugs Anti tumor drugs Antibiotics Antipsychotics Azathioprine Drug therapy Females Glucocorticoids Healthy volunteers Hepatitis b Hepatitis virus Hospital ethics committee Iron Liver Liver transplant Males Metabolic diseases Pancreas Pancreatic inflammation Pancreatic tumors Patients Platinum Splenectomy Sulfonamides Thiazide diuretics Trauma Volunteers

Corresponding Organization : First Affiliated Hospital of GuangXi Medical University

Other organizations : Fourth Affiliated Hospital of Guangxi Medical University

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Variable analysis

independent variables

Diabetes status (T2DM patients vs. normal controls)

dependent variables

Age of participants

control variables

Sex (female vs. male)
Age (similar age to T2DM patients within ± 3 years)
Absence of related diseases in normal controls
Absence of contraindications for MRI examination
Absence of liver and pancreatic tumors
Absence of splenectomy
Absence of abnormal metabolic function or metabolic diseases excluding T2DM
Absence of hepatitis virus or hepatitis B, and liver iron deposition
Absence of liver trauma or liver transplant
Absence of pancreatic inflammation and alcoholism
Absence of drug therapy for the pancreas and liver within six months

positive controls

T2DM patients

negative controls

Normal controls

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