Multiple Myeloma Cell Lines and Compounds

Cell lines (KMS11, OPM2, and ANBL6) were purchased from American Type Culture Collection (Manassas, VA, USA). MM.1S BzR cells were a gift from Dr. Brian Van Ness (U. of Minnesota) and have been described previously [25 (link)]. LTI6426 was provided by Leukogene Therapeutics, Inc. (Charleston, SC) with purity and identity that was confirmed by liquid chromatograph–mass spectrometry (LC–MS) and nuclear magnetic resonance (NMR) as shown previously [16 (link)]. Bortezomib (Catalog No. S1013), carfilzomib (Catalog No. S2853), panobinostat (Catalog No. S1030), vorinostat (Catalog No. S1047), ricolinostat (Catalog No. S8001), entinostat (Catalog No. S1053), romidepsin (Catalog No. S3020), tazmetostat (Catalog No. S7128), ML324 (Catalog No. S7296), JQ1 (Catalog No. S7110), OTX015 (Catalog No. S7360), ABBV744 (Catalog No. S8723), IBET151 (Catalog No. S2780), and GSK-LSD1 (Catalog No. S7574) were purchased from Selleck Chemicals (Houston, TX, USA).

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Robinson R.M., Basar A.P., Reyes L., Duncan R.M., Li H, & Dolloff N.G. (2022). PDI inhibitor LTI6426 enhances panobinostat efficacy in preclinical models of multiple myeloma. Cancer Chemotherapy and Pharmacology, 89(5), 643-653.

Publication 2022

KMS11 ANBL6 Bortezomib carfilzomib panobinostat vorinostat ricolinostat entinostat romidepsin tazmetostat ML324 OTX015 ABBV744 IBET151 GSK-LSD1

Abbv744 Bortezomib Carfilzomib Cell lines Cells Entinostat Liquid chromatograph Lsd1 Mass spectrometry Ml324 Ness Nuclear magnetic resonance Otx015 Panobinostat Ricolinostat Romidepsin Therapeutics Vorinostat

Corresponding Organization :

Other organizations : Medical University of South Carolina, MUSC Hollings Cancer Center

Top 5 similar protocols

Variable analysis

independent variables

Bortezomib
Carfilzomib
Panobinostat
Vorinostat
Ricolinostat
Entinostat
Romidepsin
Tazmetostat
ML324
OTX015
ABBV744
IBET151
GSK-LSD1

dependent variables

Cell growth and proliferation

control variables

Cell lines: KMS11, OPM2, ANBL6, MM.1S BzR, LTI6426

controls

Positive control: None specified
Negative control: None specified

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