Multisite Neuroimaging Protocol for CHARTER and COBRA Studies

For the CHARTER study, 3D T1-weighted MRI data were collected with General Electric 1.5T scanners at Johns Hopkins University (n = 30); Mt. Sinai School of Medicine (n = 25); University of California,San Diego (n = 47); University of Texas Medical Branch (n = 29), and the University of Washington (n = 8), as previously described [9 (link)]. For the COBRA study, 3D T1-weighted structural images and diffusion-weighted images along 64 non-collinear directions were acquired across the 2 study sites. In London, images were acquired using a Siemens Verio scanner (n = 21) and in Amsterdam initially using a Philips Intera (n = 30) and then using a Philips Ingenia (n = 40) scanner due to a scanner upgrade as previously described [14 ]. See supplementary data for further details of scanner parameters.