Custom written software in MatLab® (R2011a) processed raw angular signal data captured by the motion sensors [13 (link),15 (link),16 ]. The interpreted data displayed tremor severity, as total angular RMS amplitude, in each DOF during each task in each arm joint that was reviewed by a clinician prior to injection. The software provided a percentage contribution of the directional movements. Based upon the experienced clinician’s best judgment, a preselected total dose based on tremor amplitude was divided using the percentage contribution data and was allocated to appropriate muscles for injection. Muscles selected for injection were based upon well-known anatomical basis of movement at each joint. Dosages for subsequent injection visits were based upon comparisons of kinematics at that visit to prior kinematic data. This approach allowed the experienced clinician to use the kinematic data to tailor the injections at each joint and to ensure the most appropriate muscles were selected, making the approach generalizable in the experienced clinician’s hands.
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