Solid-Phase Peptide Synthesis

Example 4

Synthesis of Peptides

All peptides were synthesized using standard and well-established solid phase peptide synthesis using the Fmoc-strategy. Identity and purity of each individual peptide have been determined by mass spectrometry and analytical RP-HPLC. The peptides were obtained as white to off-white lyophilizes (trifluoro acetate salt) in purities of >50%. All TUMAPs are preferably administered as trifluoro-acetate salts or acetate salts, other salt-forms are also possible.

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US11872270B2. A*03 restricted peptides for use in immunotherapy against cancers and related methods (2024-01-16). Immatics Biotechnologies GmbH [DE]. Inventors: Colette Song [DE], Linus Backert [DE], Heiko Schuster [DE], Daniel Johannes Kowalewski [DE], Oliver Schoor [DE], Jens Fritsche [DE], Toni Weinschenk [DE], Harpreet Singh [DE].

Patent 2024

Acetate Cancers Hplc Immunotherapy Mass spectrometry Peptides Salt Salts

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Variable analysis

independent variables

Solid phase peptide synthesis using the Fmoc-strategy

dependent variables

Identity and purity of each individual peptide

control variables

Standard and well-established solid phase peptide synthesis
Peptides obtained as trifluoro-acetate salts or acetate salts

controls

Positive control: Not specified
Negative control: Not specified

Annotations

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