Synthesis and Characterization of ZIF-NPs

Cetylpyridinium Chloride (CAS No. 123-03-5) was purchased from the Shanghai Yien Chemical Technology Co., Ltd. (Shanghai, China). Other reagents at analytical grade were purchased from the Sinopharm Chemical Reagent Co., Ltd. (Shanghai, China). The ZnO and 2-methylimidazole were commercially available from J&K Scientific LLC (San Jose, CA, USA). The zeolitic imidazolate framework-8 nanoparticles (ZIF-NPs) were produced via the mechanochemical reaction between ZnO and 2-methylimidazole with a molar ratio of 1:2 [24 (link)]. The ZIF-NPs were characterized by scanning electron microscopy (SEM; SU8020, Hitachi Limited, Tokyo, Japan), which showed their shapes with 100–400 nm particle sizes (see Supplementary Figure S1). The enzyme-linked immunosorbent assay (ELISA) kits for assaying the reactive oxygen species (ROS), total superoxide dismutase (T-SOD), glutathione (GSH), catalase (CAT), and malondialdehyde (MDA) were purchased from the Bomei Biotechnology Co., Ltd. (Hefei, Anhui, China).