Quantification of Hippocampal Calcifications in Brain CT Scans

The brain CT scans were made with a Philips Brilliance 64-slice or 256-slice CT scanner (Philips Healthcare, Best, The Netherlands). The brain from the patient who donated her body to the Department of Anatomy was removed from the skull before scanning. The brains from the patients from the Department of Pathology were scanned surrounded by the skull. Non-contrasted thin slice reconstructions (0.8–1.0 mm) were analysed for hippocampal calcifications in different reconstructions, axial, coronal, and sagittal in the brain window setting (Center: 40 Hounsfield Units, Width: 80 Hounsfield Units) using the Philips IntelliSpace Portal 7.0 (Philips Healthcare, Best, The Netherlands). Calcifications were bilaterally scored on severity as absent, mild (one dot), moderate (multiple dots) or severe (confluent) (Fig 1) as described first by Kockelkoren et al. [8 (link)]. Calcifications on the CT scans are seen as a group of white voxels with a density similar to bone (Fig 1). The hippocampi were scored by an experienced observer. His agreement in comparison with other observers was previously investigated (kappa 0.80) [8 (link)]. The observer was blinded to the histological results.

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Peters M.E., Kockelkoren R., de Brouwer E.J., Koek H.L., Bleys R.L., Mali W.P., Hendrikse J., Rozemuller A.M, & de Jong P.A. (2018). Histological validation of calcifications in the human hippocampus as seen on computed tomography. PLoS ONE, 13(5), e0197073.

Publication 2018

Brilliance 64-slice or 256-slice CT scanner IntelliSpace Portal 7.0

Body Bone Brain Calcifications Ct scanner Ct scans Hippocampi Patients Reconstructions Seen Skull

Corresponding Organization : University Medical Center Utrecht

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Variable analysis

independent variables

Brain CT scans were made with a Philips Brilliance 64-slice or 256-slice CT scanner

dependent variables

Hippocampal calcifications
Severity of hippocampal calcifications (absent, mild, moderate, severe)

control variables

The brain from the patient who donated her body to the Department of Anatomy was removed from the skull before scanning
The brains from the patients from the Department of Pathology were scanned surrounded by the skull
Non-contrasted thin slice reconstructions (0.8–1.0 mm) were analyzed
Calcifications were bilaterally scored on severity as absent, mild (one dot), moderate (multiple dots) or severe (confluent)
The hippocampi were scored by an experienced observer
The observer was blinded to the histological results

positive controls

Not explicitly mentioned

negative controls

Not explicitly mentioned

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