Preoperative USPIO-enhanced MRI was conducted using ferumoxtran-10 (Ferrotran, SPL Medical B.V., investigational product), administered intravenously (2.6 mg/kg body weight) 24-36 h before the scan, as previously described [16] . MRI was performed on a 3-T MRI system (Magnetom Prisma, Siemens Healthcare). Butylscopolamine and glucagon were administered to minimise peristaltic motion, unless contraindicated. Patients were positioned feet first supine, with body phased array coils around the upper abdomen. The scan range was from diaphragm to aortic bifurcation. Images were acquired with repeated breath-holds of maximally 20 s on expiration. MRI sequences included T2-weighted HASTE for anatomical reference, T1-weighted VIBE DIXON for LN localisation, and fat-suppressed T2*-weighted multi gradient echo (mGRE) sequence for USPIO visualisation, mGRE images were reconstructed to a single T2*weighted computed echo time (TE) of 12 ms [17] . Table 1 describes the technical details of the MR sequences.
Protocol detail
USPIO-Enhanced MRI for Lymph Node Evaluation
Partial Protocol Preview
This section provides a glimpse into the protocol.
The remaining content is hidden due to licensing restrictions, but the full text is available at the following link:
Access Free Full Text.
Corresponding Organization : Radboud University Nijmegen
Other organizations : Osaka University, University Medical Center Utrecht, Radboud Institute for Molecular Life Sciences
Top 5 similar protocols
Variable analysis
independent variables
- Ferumoxtran-10 (Ferrotran, SPL Medical B.V., investigational product)
- Administration of ferumoxtran-10 (2.6 mg/kg body weight) 24-36 h before the scan
- MRI images acquired using T2-weighted HASTE, T1-weighted VIBE DIXON, and fat-suppressed T2*-weighted multi gradient echo (mGRE) sequence
- 3-T MRI system (Magnetom Prisma, Siemens Healthcare)
- Butylscopolamine and glucagon administration to minimize peristaltic motion, unless contraindicated
- Positioning of patients feet first supine, with body phased array coils around the upper abdomen
- Scan range from diaphragm to aortic bifurcation
- Images acquired with repeated breath-holds of maximally 20 s on expiration
Annotations
Based on most similar protocols
Etiam vel ipsum. Morbi facilisis vestibulum nisl. Praesent cursus laoreet felis. Integer adipiscing pretium orci. Nulla facilisi. Quisque posuere bibendum purus. Nulla quam mauris, cursus eget, convallis ac, molestie non, enim. Aliquam congue. Quisque sagittis nonummy sapien. Proin molestie sem vitae urna. Maecenas lorem.
Sign up for free or login to display all annotations
As authors may omit details in methods from publication, our AI will look for missing critical information across the 5 most similar protocols.
About PubCompare
Our mission is to provide scientists with the largest repository of trustworthy protocols and intelligent analytical tools, thereby offering them extensive information to design robust protocols aimed at minimizing the risk of failures.
We believe that the most crucial aspect is to grant scientists access to a wide range of reliable sources and new useful tools that surpass human capabilities.
However, we trust in allowing scientists to determine how to construct their own protocols based on this information, as they are the experts in their field.
Ready to get started?
Sign up for free.
Registration takes 20 seconds.
Available from any computer
No download required
Revolutionizing how scientists
search and build protocols!