Genome-wide Breast Cancer Associations
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Other organizations : University of Cambridge, University of Washington, QIMR Berghofer Medical Research Institute, University of Toronto, Cancer Research UK Cambridge Center, Centre hospitalier universitaire de Québec, Université Laval, St. Jude Children's Research Hospital, The Netherlands Cancer Institute, German Cancer Research Center, Heidelberg University, University of Queensland, Harvard University, Johns Hopkins Medicine, Johns Hopkins University, Amsterdam UMC Location VUmc, University of Chicago, Helsinki University Hospital, University of Helsinki, University of California, Irvine, N.N. Alexandrov National Cancer Centre, Queen's University, The University of Texas MD Anderson Cancer Center, Fred Hutch Cancer Center, McGill University and Génome Québec Innovation Centre, Comprehensive Cancer Center Erlangen, Universitätsklinikum Erlangen, Spanish National Cancer Research Centre, Institute of Biochemistry and Genetics of Ufa Scientific Centre, Russian Academy of Sciences, City of Hope, Gentofte Hospital, Copenhagen University Hospital, European Institute of Oncology, Oslo University Hospital, Karolinska Institutet, Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Centre International de Recherche sur le Cancer, National Cancer Institute, Lund University, University of Sheffield, BC Cancer Agency, University of Tübingen, Institute for Prevention and Occupational Medicine, Vanderbilt University, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos, Centro de Investigación Biomédica en Red de Cáncer, Instituto de Investigación Sanitaria de Santiago, Servicio Gallego de Salud, Fundación Pública Galega de Medicina Xenómica, Complejo Hospitalario Universitario de Santiago, American Cancer Society, Roswell Park Comprehensive Cancer Center, National University Health System, National University of Singapore, Seoul National University, Medizinische Hochschule Hannover, Westmead Institute for Medical Research, University of Sydney, Erasmus MC, Inserm, Centre de recherche en Epidémiologie et Santé des Populations, Imperial College London, Mayo Clinic, Fox Chase Cancer Center, Leiden University Medical Center, London School of Hygiene & Tropical Medicine, University of Southampton, University of Westminster, Brigham and Women's Hospital, Bashkir State University, Leipzig University, Universität Hamburg, University Medical Center Hamburg-Eppendorf, Institute of Cancer Research, Breast Cancer Now, Curtin University, Shanghai Cancer Institute, University Hospital of Heraklion, Cancer Council Victoria, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, McGill University, Huntsman Cancer Institute, University of Utah, University of Oulu, Oulu University Hospital, Pomeranian Medical University, Centre Hospitalier de l’Université de Montréal, University Hospital Cologne, University of Southern California, University of Massachusetts Amherst, Mayo Clinic in Florida, University of Eastern Finland, University of Western Australia, Hong Kong Sanatorium and Hospital, Erasmus MC Cancer Institute, University of Melbourne, Kaohsiung Medical University, Institute of Biomedical Sciences, Academia Sinica, Aichi Cancer Center, National Center for Global Health and Medicine, University Hospital Ulm, Cancer Prevention Institute of California, Nagano Matsushiro General Hospital, Ollscoil na Gaillimhe – University of Galway, Seoul St. Mary's Hospital, Cancer Center of Hawaii, University of Hawaiʻi at Mānoa, University of Hawaii System, Soonchunhyang University Hospital, University of Ulsan, Asan Medical Center, Ulsan College, Carmel Medical Center, The Maria Sklodowska-Curie National Research Institute of Oncology, German Breast group, University of Warwick, Macedonian Academy of Sciences and Arts, Fondazione IRCCS Istituto Nazionale dei Tumori, Cancer Research Malaysia, University of California, San Diego, Nagoya University, The Alfred Hospital, Technical University of Munich, Hospital Monte Naranco, University College London, University Malaya Medical Centre, Sorbonne Paris Cité, KU Leuven, University of Copenhagen, Cancer Genetics (United States), University of New Mexico, Seoul National University Hospital, FIRC Institute of Molecular Oncology, Ludwig-Maximilians-Universität München, Städtisches Klinikum Karlsruhe, National Institute of Environmental Health Sciences, National Cancer Institute of Thailand, King's College London, Guy's Hospital, Case Western Reserve University, John Hunter Hospital, University of Kansas Medical Center, China Medical University, National Center for Tumor Diseases, Krebsregister Saarland, Columbia University, Ministry of Public Health, University Cancer Center Hamburg, Wellcome Centre for Human Genetics, University of Oxford, Klinikum Mittelbaden, Olgahospital, Cancer Registry of Norway, Helios Hospital Berlin-Buch, University Medical Center Utrecht, Universität Ulm, Stanford University, Subang Jaya Medical Centre, National Defense Medical Center, Tri-Service General Hospital, Shanghai Municipal Center For Disease Control Prevention, University of California, San Francisco, UCSF Helen Diller Family Comprehensive Cancer Center, Royal Brisbane and Women's Hospital, Dartmouth College, Stockholm South General Hospital
Protocol cited in 55 other protocols
Variable analysis
- Genome-wide or candidate analysis at a significance level P<5x10^-8
- Associations previously reported for overall breast cancer, ER-negative or ER-positive breast cancer, in BRCA1 or BRCA2 carriers, or in meta-analyses of these categories
- Breast cancer risk variants
- Only one SNP per 500kb interval was included, unless joint analysis provided clear evidence (P<5x10^-8) of more than one independent signal
- The analysis of credible risk variants (CRVs) was restricted to regions where the most significant signal had a P-value<10^-7 in Europeans (77 regions)
- CRVs were defined as those whose P-value was within two orders of magnitude of the most significant P-value
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