The compound pexidartinib (PLX3397; S7818) was purchased from Selleck Chemicals and formulated in irradiated D10001i Rodent Diet standard chow by Research Diets at a dose of 290 mg per kilogram of chow. At P20 WT and Cnp-Cre Jab1fl/fl mice were fed with standard diet or PLX3397 (290 mg/kg) chow for 21 days to reduce microglia cells by more than 99% in the CNS, as previously described (25 (link)).
Free full text: Click here