The Kailuan study is a prospective cohort study conducted in the Kailuan community in Tangshan, Republic of China, which is a large, modern city southeast of Beijing. Detailed study design and procedures have been described in detail.3 (link),12 (link),13 (link),14 (link),15 (link),16 (link) Since June 2006, a total of 101 510 adult participants, including 81 110 men and 20 400 women, were enrolled from 11 hospitals in the Kailuan community and underwent questionnaire assessments, clinical examinations, and laboratory tests. All participants were then followed up every 2 years and the incidence of chronic diseases (eg, CVD) was recorded annually. In the present study, CHS trajectories were developed from 2006 to 2010 to predict CVD risk from 2010 to 2015. Data analysis was performed from January 1, 2006, to December 31, 2015.
The study protocol was approved by the ethics committee of the Kailuan General Hospital. All participants provided written informed consent; they did not receive financial compensation. This study followed the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) reporting guideline for cohort studies.
Included in the present analyses were 74 701 participants free of CVD and cancer in or before 2010 (ie, the baseline of present analyses). The flowchart of the participant selection process is shown in the eFigure in the Supplement. Compared with those who were not included in the present analysis owing to missing 2008 and 2010 CHSs, included participants had similar 2006 CHSs (mean, 8.7 vs 8.5 in 2006) but were older (mean age, 50.7 vs 49.0 years in 2006) and had a smaller proportion of men (77.9% vs 86.4%).
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