Zein-based Pharmaceutical Formulation Development

Zein was purchased from Sigma (Z3625, with a reported protein content of 86.06% w/w [17 (link)] and molecular weight primarily of 22–24 kDa [18 (link)], corresponding to α-zein [19 (link)]). For the complete protein analysis of zein (Sigma Z3625) by sodium dodecyl sulfate polyacrylamide gel electrophoresis readers are referred to [20 (link)]. Hydroxypropyl methylcellulose (HPMC-Methocel^® K4M Premium CR, i.e., premium grade cellulose ether type 2208, 4000 cps [21 ]) and ethyl cellulose (EC—Ethocel Standard 10 Premium, i.e., premium grade cellulose ethyl ether, 10 cps [21 ]) were provided by Colorcon and The Dow Chemical Company, respectively. Lactose monohydrate (Foremost #316 Fast Flo NF) and Polyvinylpyrrolidone (PVP) K30 were supplied by Foremost Farms and Shanghai Yuking Water Soluble Material Tech Co., respectively. Sodium lauryl sulphate was bought from Acros Organics. Titanium dioxide was obtained from Xilong Scientific Co. and magnesium stearate from Laboratory Rasayan. Dibasic calcium phosphate anhydrous (DCP, Emcompress-JRS Pharma) and microcrystalline cellulose (MCC—Vivapur^® 102) were gifted by Rimon Chemical Co. Propranolol HCl was generously donated by Hikma Pharmaceuticals.

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Berardi A., Abdel Rahim S., Bisharat L, & Cespi M. (2019). Swelling of Zein Matrix Tablets Benchmarked against HPMC and Ethylcellulose: Challenging the Matrix Performance by the Addition of Co-Excipients. Pharmaceutics, 11(10), 513.

Publication 2019

Titanium dioxide

Cellulose Dibasic calcium phosphate Ethyl cellulose Ethyl ether Hydroxypropyl methylcellulose Lactose Magnesium stearate Methocel Microcrystalline cellulose Pharmaceuticals Polyvinylpyrrolidone Propranolol hcl Protein Protein a Sodium dodecyl sulfate polyacrylamide gel electrophoresis Sodium lauryl sulphate Titanium dioxide Vivapur 102 Zein

Corresponding Organization : Applied Science Private University

Other organizations : University of Jordan, Università di Camerino

Top 5 similar protocols

Variable analysis

independent variables

Zein (Sigma Z3625)
Hydroxypropyl methylcellulose (HPMC-Methocel® K4M Premium CR)
Ethyl cellulose (EC—Ethocel Standard 10 Premium)
Lactose monohydrate (Foremost #316 Fast Flo NF)
Polyvinylpyrrolidone (PVP) K30
Sodium lauryl sulphate
Titanium dioxide
Magnesium stearate
Dibasic calcium phosphate anhydrous (DCP, Emcompress-JRS Pharma)
Microcrystalline cellulose (MCC—Vivapur® 102)
Propranolol HCl

dependent variables

Protein content of zein (Sigma Z3625)
Molecular weight of zein (Sigma Z3625)
Zein composition (α-zein)

control variables

Protein content of zein (Sigma Z3625): 86.06% w/w
Molecular weight of zein (Sigma Z3625): 22–24 kDa

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