In period 2, children underwent the same standardized examinations as in period 1. Axial length (AL), corneal curvature, corneal astigmatism, and anterior chamber depth (ACD) were obtained using a non-contact partial coherence interferometer (IOL-Master 500: 7.7.4 software version, 1.3375 Group Refractive Index, Carl Zeiss Meditec AG, Germany). The signal-to-noise ratio for AL readings is greater than 2.0. Pupil diameter was measured using an autorefractor (NIDEK, AR-1, Japan). Accommodative amplitude was measured monocularly using the push-up technique. IOP was measured using a non-contact tonometer (TX-20, 1.5.1.0 software version, Canon, Japan). Details of the examination methods for cycloplegic autorefraction, AL, corneal curvature, corneal astigmatism, ACD, pupil diameter, accommodative amplitude, IOP, and discomfort symptoms have been published elsewhere and are available in the Supplementary File (28 (link), 29 (link)). The primary outcome was changes in AL.
At the randomized visit and subsequent 4-month follow-up, each participant was given four bottles of eyedrops. OK lenses, lens suction holders, lens cases, and care solutions were checked and recorded at each visit. The average weekly use of eye drops and the wearing of OK lenses were assessed using a paper questionnaire.
At the randomized visit and subsequent 4-month follow-up, each participant was given four bottles of eyedrops. OK lenses, lens suction holders, lens cases, and care solutions were checked and recorded at each visit. The average weekly use of eye drops and the wearing of OK lenses were assessed using a paper questionnaire.
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