The datasets used here were derived from a study previously reported [34 (link)]. Brie y, animals were randomly assigned to two treatments groups and treated with pentylenetetrazole (PTZ, treated group) or saline (control group) for a period of 4 weeks. A third treatment group consisted of animals who received one injection only and these data are not used within this paper. Throughout the treatment period urine was collected from the animals in collection tubes containing 1% sodium azide surrounded by ice. The animals had no access to food during this time but had free access to water. At the end of the treatment period brain regions were isolated and metabolites extracted as previously described [34 (link)]. NMR spectra were acquired and the spectra were integrated into bin regions of 0.04 ppm using AMIX (Bruker) excluding the water regions (4.0-6.0 ppm).
The urine dataset used herein was constructed from NMR spectra acquired from urine collected on day ten of the study; it consists of 18 spectral profiles (from 9 treated and 9 control animals) over 189 spectral bin regions.
The brain dataset comes from animals in the control group only with spectra acquired from tissues from four brain regions: the pre-frontal cortex, hippocampus, cerebellum and brainstem. In total, there are 33 spectral profiles over 164 spectral bin regions.
The urine dataset used herein was constructed from NMR spectra acquired from urine collected on day ten of the study; it consists of 18 spectral profiles (from 9 treated and 9 control animals) over 189 spectral bin regions.
The brain dataset comes from animals in the control group only with spectra acquired from tissues from four brain regions: the pre-frontal cortex, hippocampus, cerebellum and brainstem. In total, there are 33 spectral profiles over 164 spectral bin regions.
Free full text: Click here
