Synthesis of Ursodeoxycholic Acid Conjugate
Corresponding Organization :
Other organizations : University of Auckland, Inserm, Aix-Marseille Université, Molécules de Communication et Adaptation des Micro-organismes, Centre National de la Recherche Scientifique
Variable analysis
- Ursodeoxycholic acid (0.045 g, 0.115 mmol)
- Di-tert-butyl butane-1,4-diylbis((3-aminopropyl)carbamate) (6a) (0.023 g, 0.0573 mmol)
- EDC·HCl (0.033 g, 0.172 mmol)
- HOBt (0.008 g, 0.0573 mmol)
- DIPEA (0.040 mL, 0.229 mmol)
- Di-tert-butyl butane-1,4-diylbis((3-((R)-4-((3R,5S,7S,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanamido)propyl)carbamate) (0.061 g, 92%)
- The di-TFA salt 8a (0.005 g, 98%)
- Following general procedure B
- Following general procedure C
- A sub-sample of the product (0.005 g, 0.00434 mmol)
Annotations
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