Assessing Corticospinal Excitability Changes

The secondary outcome measures will include the resting motor threshold (states the general excitability of the neuromotor axis in the target muscle), the MEP amplitude (expresses the trans-synaptic activation of corticospinal neurons) and latency (defines the time which is needed for signal transmission from the motor cortex to the recording electrode of the target muscle) [67 (link)], and all clinical assessments. We will quantify the resting motor threshold and the MEP amplitude and latency using a single pulse TMS and two independent physiotherapists will both perform all clinical assessments to each participant.

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Sokratous D., Charalambous C.C., Papanicolaou E.Z., Michailidou K, & Konstantinou N. (2023). Investigation of in-phase bilateral exercise effects on corticospinal plasticity in relapsing remitting multiple sclerosis: A registered report single-case concurrent multiple baseline design across five subjects. PLOS ONE, 18(3), e0272114.

Publication 2023

Axis Motor cortex Muscle Neurons Physiotherapists Pulse Transmission

Corresponding Organization : Cyprus Institute of Neurology and Genetics

Other organizations : University of Nicosia

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Variable analysis

independent variables

Not explicitly mentioned

dependent variables

Resting motor threshold (states the general excitability of the neuromotor axis in the target muscle)
MEP amplitude (expresses the trans-synaptic activation of corticospinal neurons)
MEP latency (defines the time which is needed for signal transmission from the motor cortex to the recording electrode of the target muscle)
All clinical assessments

control variables

Two independent physiotherapists will both perform all clinical assessments to each participant

positive controls

Not mentioned

negative controls

Not mentioned

Annotations

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