D1/D5 Receptor Agonists in Auditory Memory

The D1/D5 dopamine receptor-selective agonists SKF38393 (Sigma), SKF83822 (Tocris) and SKF83959 (Sigma), and the D1/D5 dopamine receptor-selective antagonist SCH23390 (Sigma) were dissolved in 0.9% saline and adjusted to ≈ pH 7. The doses used – that is, 0.06 μg/μL = 0.2 mM SKF38393 and 0.5 μg/μL = 1.25 mM SKF83959 for intracortical injections, and 5 mg/kg SKF38393, 0.625 mg/kg SKF83822, 2.5 mg/kg SKF83959, and 0.1 mg/kg SCH23390 for intraperitoneal injections – were based on our previous studies on mechanisms of FM discrimination memory in the gerbil auditory cortex [21 (link),22 (link)] in conjunction with studies on the pharmacological efficacy of the agonists [27 (link)].