GWAS of SSRI Treatment Response

DNA from PGRN-AMPS SSRI trial patients was genotyped at the RIKEN Center
for Genomic Medicine (Yokohama, Japan) using Illumina human 610-Quad BeadChips
(Illumina, San Diego, CA, USA), as described previously.^{11 (link), 37 (link)} GWAS were performed using approximately 7.5 million
SNPs. Patients were removed from the analysis for non-compliance or
non-Caucasian heritage. Baseline analyses were adjusted for age and sex.
Metabolite concentrations and changes in metabolite concentrations after SSRI
treatment were tested for association with QIDS-C16 percent change, response and
remission. See Supplementary Text for details.

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Gupta M., Neavin D., Liu D., Biernacka J., Hall-Flavin D., Bobo W.V., Frye M.A., Skime M., Jenkins G.D., Batzler A., Kalari K., Matson W., Bhasin S.S., Zhu H., Mushiroda T., Nakamura Y., Kubo M., Wang L., Kaddurah-Daouk R, & Weinshilboum R.M. (2016). TSPAN5, ERICH3 and selective serotonin reuptake inhibitors in major depressive disorder: pharmacometabolomics-informed pharmacogenomics. Molecular Psychiatry, 21(12), 1717-1725.

Publication 2016

Illumina human 610-Quad BeadChips

Caucasian Gwas Human Patients

Corresponding Organization :

Other organizations : Mayo Clinic, WinnMed, Bedford VA Research Corporation, Duke University, RIKEN Center for Integrative Medical Sciences, University of Chicago

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Variable analysis

independent variables

PGRN-AMPS SSRI trial patients' DNA genotyped at the RIKEN Center for Genomic Medicine (Yokohama, Japan) using Illumina human 610-Quad BeadChips

dependent variables

Metabolite concentrations and changes in metabolite concentrations after SSRI treatment
QIDS-C16 percent change, response and remission

controls

Patients were removed from the analysis for non-compliance or non-Caucasian heritage.

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