The study was conducted from 2015 to 2018 in the Department of Endocrinology, Piekary Medical Centre, St. Luke’s Local Hospital in Piekary Śląskie, Poland.
Blood samples were taken from patients in the morning, before breakfast, and 1 mL of blood collected as part of routine testing was preserved for further analysis, which after centrifugation was frozen and stored at −70 degrees Celsius.
The value of the HOMA-IR (Homeostatic model assessment) index was calculated using the following formula:
HOMA-IR = fasting insulinemia (mU/mL) × fasting glycemia (mmol/L)/22.5 [19 (link)].
The value of the METS-IR (The metabolic score for insulin resistance) was calculates as (In ((2 × fasting glucose) (mg/dL) + TG (mg/dL) × BMI)/(Ln (HDL-C) (mg/dL)) [14 (link)].
TyG index was computed using the formula following: In [fasting glucose (mg/dL) × TG (mg/dL)/2] [19 (link)].
TyG-BMI index was defined as: [fasting plasma glucose (mg/dL) × fasting triglicerydes (mg/dL)/2] × BMI [20 (link)].
TyG-WC was defined as: [fasting glucose (mg/dL) × TG (mg/dL)/2 × WC] [20 (link)].
LCI was calculated using the following formula: ((TC (mmol/L) × TG (mmol/L) × LDL-C (mmol/L))/HDL-C (mmol/L)) [15 (link)].
Castelli’s risk index-I was calculated according to the following formula [9 (link)] = (TC/HDL-C).
Castelli’s risk index-II was calculated according to the following formula [9 (link)] = (LDL-C/HDL-C).
Atherogenic coefficient (AC) was calculated according to the following formula [9 (link)] = (TC-HDL-C/HDL-C).
Atherogenic index of plasma (AIP) was calculated according to the following formula [9 (link)] = (log(TG/HDL-C)).
Trigliceryde to HDL-cholesterol was calculated according to the following formula [9 (link)] = (TG/HDL-C).
Anthropometric parameters were measured with the use of standard methods in the morning. These measurements included body weight [kg], height [cm], waist circumference [cm], and hip circumference [cm].
BMI was calculated according to the following formula [21 ]:
BMI = body weight [kg]/height [m]2;
WHR was calculated according to the following formula [22 ]:
WHR = waist circumference [cm]/hip circumference [cm];
WhtR was calculated according to the following formula [22 ]:
WHtR = waist circumference [cm]/height [cm];
BAI was calculated according to the following formula [23 (link)]:
BAI = (hip circumference [cm]/height [m]1.5) [18 (link)];
VAI was calculated according to the following formula [19 (link)]:
VAI = [waist circumference [cm]/(36.58 + (1.89 × BMI))] × (triglyceride concentration [mmol/L]/0.81) × (1.52/HDL concentration [mmol/L]);
LAP was calculated according to the following formula [19 (link)]:
LAP = (waist circumference [cm] − 58) × (triglyceride concentration [mmol/L]);
BRI was calculated according to the following formula [24 (link)]:
BRI = 365.2 − 365.5 × √(1 − (((WC/2π)2)/[(0.5 × height)]2);
ABSI was calculated according to the following formula [24 (link)]:
ABSI = WC[m]/[(BMI)2/3) × (height [m])1/2)].
Blood samples were taken from patients in the morning, before breakfast, and 1 mL of blood collected as part of routine testing was preserved for further analysis, which after centrifugation was frozen and stored at −70 degrees Celsius.
The value of the HOMA-IR (Homeostatic model assessment) index was calculated using the following formula:
HOMA-IR = fasting insulinemia (mU/mL) × fasting glycemia (mmol/L)/22.5 [19 (link)].
The value of the METS-IR (The metabolic score for insulin resistance) was calculates as (In ((2 × fasting glucose) (mg/dL) + TG (mg/dL) × BMI)/(Ln (HDL-C) (mg/dL)) [14 (link)].
TyG index was computed using the formula following: In [fasting glucose (mg/dL) × TG (mg/dL)/2] [19 (link)].
TyG-BMI index was defined as: [fasting plasma glucose (mg/dL) × fasting triglicerydes (mg/dL)/2] × BMI [20 (link)].
TyG-WC was defined as: [fasting glucose (mg/dL) × TG (mg/dL)/2 × WC] [20 (link)].
LCI was calculated using the following formula: ((TC (mmol/L) × TG (mmol/L) × LDL-C (mmol/L))/HDL-C (mmol/L)) [15 (link)].
Castelli’s risk index-I was calculated according to the following formula [9 (link)] = (TC/HDL-C).
Castelli’s risk index-II was calculated according to the following formula [9 (link)] = (LDL-C/HDL-C).
Atherogenic coefficient (AC) was calculated according to the following formula [9 (link)] = (TC-HDL-C/HDL-C).
Atherogenic index of plasma (AIP) was calculated according to the following formula [9 (link)] = (log(TG/HDL-C)).
Trigliceryde to HDL-cholesterol was calculated according to the following formula [9 (link)] = (TG/HDL-C).
Anthropometric parameters were measured with the use of standard methods in the morning. These measurements included body weight [kg], height [cm], waist circumference [cm], and hip circumference [cm].
BMI was calculated according to the following formula [21 ]:
BMI = body weight [kg]/height [m]2;
WHR was calculated according to the following formula [22 ]:
WHR = waist circumference [cm]/hip circumference [cm];
WhtR was calculated according to the following formula [22 ]:
WHtR = waist circumference [cm]/height [cm];
BAI was calculated according to the following formula [23 (link)]:
BAI = (hip circumference [cm]/height [m]1.5) [18 (link)];
VAI was calculated according to the following formula [19 (link)]:
VAI = [waist circumference [cm]/(36.58 + (1.89 × BMI))] × (triglyceride concentration [mmol/L]/0.81) × (1.52/HDL concentration [mmol/L]);
LAP was calculated according to the following formula [19 (link)]:
LAP = (waist circumference [cm] − 58) × (triglyceride concentration [mmol/L]);
BRI was calculated according to the following formula [24 (link)]:
BRI = 365.2 − 365.5 × √(1 − (((WC/2π)2)/[(0.5 × height)]2);
ABSI was calculated according to the following formula [24 (link)]:
ABSI = WC[m]/[(BMI)2/3) × (height [m])1/2)].
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