Standardized TACE Procedure for Tumor Treatment

The TACE procedure is consistent across centers, and as described in our previous report on the TACE procedure (10 (link)), all TACE procedures were performed by 2 experienced minimally invasive interventionalists under local anesthesia through a traditional femoral approach. After routine angiography using a 5F RH catheter (Terumo, Tokyo, Japan), superselective arterial cannulation with a microcatheter (Terumo) was used to access the branch of the feeding artery to the tumor. Doxorubicin (Haizheng Pharmaceutical, Taizhou, China) and lipiodol (Laboratoire Guerbet, Paris, France) were thoroughly mixed and injected into the tumor-nourishing blood vessels and then 560–710 μm gelatin sponge particles (ALICON Pharmaceutical, Hangzhou, China) were administered until blood flow almost stopped. The dosage of lipiodol was 5–20 mL, and the dosage of doxorubicin was 50–70 mg. The actual dose was based on the patient's liver function status, tumor burden, and the patient's body surface area.

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Xia W.L., Zhao X.H., Guo Y., Hu H.T., Cao G.S., Li Z., Fan W.J., Xu S.J, & Li H.L. (2023). Transarterial Chemoembolization Combined With Apatinib Plus PD-1 Inhibitors for Hepatocellular Carcinoma With Portal Vein Tumor Thrombus: A Multicenter Retrospective Study. Clinical and Translational Gastroenterology, 14(5), e00581.

Publication 2023

5F RH catheter microcatheter lipiodol

Angiography Artery Blood flow Blood tumor vessels Body surface area Cannulation Catheter Doxorubicin Femoral Gelatin Lipiodol Liver Local anesthesia Pharmaceutical Sponge Tace Tumor Tumor burden

Corresponding Organization : Zhengzhou University

Other organizations : Henan Provincial People's Hospital, First Affiliated Hospital of Zhengzhou University, Sun Yat-sen University, Sun Yat-sen University Cancer Center

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Variable analysis

independent variables

Superselective arterial cannulation with a microcatheter to access the branch of the feeding artery to the tumor
Injection of a mixture of doxorubicin and lipiodol into the tumor-nourishing blood vessels
Administration of 560–710 μm gelatin sponge particles until blood flow almost stopped

dependent variables

Tumor response to the TACE procedure

control variables

The TACE procedure is consistent across centers
All TACE procedures were performed by 2 experienced minimally invasive interventionalists under local anesthesia through a traditional femoral approach
The dosage of lipiodol (5–20 mL) and doxorubicin (50–70 mg) was based on the patient's liver function status, tumor burden, and body surface area

controls

Positive control: Not specified
Negative control: Not specified

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