Community-based referral cytology was reported using the Bethesda nomenclature, including the categories “Normal for intraepithelial lesion or malignancy” (NILM), “atypical squamous cells of undermined significance” (ASC-US), “low-grade squamous intraepithelial lesion” (LSIL), “atypical squamous cells, favor high-grade” (ASC-H), and “high-grade squamous intraepithelial lesion” (HSIL)19 (link). HPV genotyping was performed using the Linear Array (LA) HPV Genotyping Test (Roche Molecular Diagnostics, Branchburg, NJ) according to the manufacturer’s instructions, with slight modifications 23 (link),24 (link).
Protocol detail
Community-based Referral Cytology and HPV Genotyping
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Atypical squamous cells
Cytology
High grade squamous intraepithelial lesion
Low grade squamous intraepithelial lesion
Malignancy
Molecular diagnostics
Corresponding Organization :
Other organizations : National Cancer Institute, University of Oklahoma Health Sciences Center
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Variable analysis
independent variables
- HPV genotyping using the Linear Array (LA) HPV Genotyping Test
- Bethesda nomenclature categories: 'Normal for intraepithelial lesion or malignancy' (NILM), 'atypical squamous cells of undermined significance' (ASC-US), 'low-grade squamous intraepithelial lesion' (LSIL), 'atypical squamous cells, favor high-grade' (ASC-H), and 'high-grade squamous intraepithelial lesion' (HSIL)
- Not explicitly mentioned
- Not specified
- Not specified
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