Example 3
3 g of the compound (2) obtained in the previous step was dissolved in 30 ml of tetrahydrofuran, and cooled to 0° C. 2.5 g of lithium aluminum hydride was added in batches, heated to room temperature and stirred for 3 hrs. 10 ml of a 50 wt % sodium hydroxide solution was added, and then 30 ml of dichloromethane was added. The organic layer was separated, washed with water, dried over anhydrous sodium sulfate, concentrated under reduced pressure, and separated by column chromatography (dichloromethane:methanol:aqueous ammonia 20:1:0.01 vol/vol/vol), to obtain 2.12 g of a yellow sticky product (3). 1HNMR (400 MHz, CDCl3): δ=7.45-7.21 (m, 10H), 3.56 (s, 4H), 3.48-3.39 (m, 2H), 2.49-2.35 (m, 4H), 2.34-2.30 (m, 2H), 2.29-2.26 (m, 4H), 1.61-1.55 (m, 2H), 1.41-1.35 (m, 2H), 1.34-1.25 (m, 2H); [M+H]: 352.5.
