Lead Acetate Exposure in Rats

The experimental animals were exposed to Pb acetate at 50 mg/kg (Sigma-Aldrich, St. Louis, MO, USA) [17 (link)] from the 35th day to the 90th postnatal day by intragastric gavage. The control group received distilled water (H₂O_dest.), in the same volume as the exposed group. Gavage administration was used by our group in different models of exposure to toxicants [57 (link),58 (link),59 (link)]. The animals were weekly weighed for dose adjustment and verification of possible changes in body mass due to metal effects.

Free full text: Click here

Alves Oliveira A.C., Dionizio A., Teixeira F.B., Bittencourt L.O., Nonato Miranda G.H., Oliveira Lopes G., Varela E.L., Nabiça M., Ribera P., Dantas K., Leite A., Buzalaf M.A., Monteiro M.C., Maia C.S, & Lima R.R. (2020). Hippocampal Impairment Triggered by Long-Term Lead Exposure from Adolescence to Adulthood in Rats: Insights from Molecular to Functional Levels. International Journal of Molecular Sciences, 21(18), 6937.

Publication 2020

Pb acetate

Acetate Animals Body Experimental animals Gavage Metal

Corresponding Organization : Universidade Federal do Pará

Other organizations : Universidade de São Paulo

Top 5 similar protocols

Protocol cited in 1 other protocol

Variable analysis

independent variables

Exposure to Pb acetate at 50 mg/kg

dependent variables

Changes in body mass due to metal effects

control variables

Administration volume of distilled water (H2Odest.) for the control group

controls

Negative control: Distilled water (H2Odest.) administration

Annotations

Based on most similar protocols

Etiam vel ipsum. Morbi facilisis vestibulum nisl. Praesent cursus laoreet felis. Integer adipiscing pretium orci. Nulla facilisi. Quisque posuere bibendum purus. Nulla quam mauris, cursus eget, convallis ac, molestie non, enim. Aliquam congue. Quisque sagittis nonummy sapien. Proin molestie sem vitae urna. Maecenas lorem.

As authors may omit details in methods from publication, our AI will look for missing critical information across the 5 most similar protocols.

About PubCompare

Our mission is to provide scientists with the largest repository of trustworthy protocols and intelligent analytical tools, thereby offering them extensive information to design robust protocols aimed at minimizing the risk of failures.

We believe that the most crucial aspect is to grant scientists access to a wide range of reliable sources and new useful tools that surpass human capabilities.

However, we trust in allowing scientists to determine how to construct their own protocols based on this information, as they are the experts in their field.

Ready to get started?

Revolutionizing how scientists
search and build protocols!