Pharmacological Modulation of Memory Reconsolidation

All drugs were administered systemically at previously established doses and timepoints. Mifepristone (Generon, UK) was injected at 30 mg/kg (60 mg/ml in propylene glycol, s.c.) immediately after memory reactivation (Pitman et al. 2011 (link)). DL-propranolol (Sigma, UK) was injected at 10 mg/kg (10 mg/ml in saline, i.p.) immediately after reactivation (Debiec and LeDoux 2004 (link); Pitman et al. 2011 (link)). (+/−)-SKF38393 (Sigma, UK) was injected at 5 mg/kg (5 mg/ml in 5% DMSO in saline, i.p.) 5 min before reactivation (de Lima et al. 2011 (link)). Nefiracetam (Sigma, UK) was injected at 3 mg/kg (6 mg/ml in saline, i.p.) 1 h before reactivation (Yoshii et al. 1997 (link)). SCH23390 (Tocris, UK) was injected at 0.1 mg/kg (0.1 mg/ml in saline, i.p.) 30 min before reactivation (Heath et al. 2015 (link)). Modafinil (Sigma, UK) was injected at 5 mg/kg (10 mg/ml in 50% DMSO in saline, i.p.) 60 min prior to reactivation (Shanmugasundaram et al. 2015 (link)). All i.p. injections were administered to the same (right) side of the abdomen. Allocation to drug treatment was fully randomised within each experimental cohort of 8 rats.