Genetically Modified Mouse Models

Brd9-flox mice (Strain NO. T008489), LysM-Cre mice (Strain NO. T003822), and WT C57BL/6J mice (Strain NO. N000013) from GemPharmatech (Nanjing, China) and tdTomato (Strain NO. 007909) mouse line^{62 (link)} from Jackson Laboratory (Maine, USA) were used and cross-bred in this study. All mice were used for analysis regardless of sex. All mice were housed in pathogen-free conditions with constant ambient temperature (22 ± 2 °C) and humidity (55 ± 10%), with an alternating 12-h light/dark cycle. All mice were euthanized by carbon dioxide overdose followed by cervical dislocation. All animal studies were approved by the Institutional Animal Care and Use Committee at Ninth People’s Hospital, School of Medicine, Shanghai Jiao Tong University (SH9H-2022-A926-1).