Dynamic HPV Transmission and Cervical Cancer Modeling

A dynamic model of HPV transmission and vaccination (implemented in Microsoft Visual Studio C++), coupled with a deterministic Markov model of the natural history of CIN and cervical screening and invasive cervical cancer survival (implemented using TreeAge Pro 2014, TreeAge Software, Inc., MA, USA), was used to simulate cervical disease and screening in NZ. This model platform, adaptable to different settings, has been previously used to evaluate various cervical screening and follow-up management strategies in Australia, NZ and England [10 ,15 (link),16 (link),17 ,18 ,19 (link),20 ,21 (link)]. Most recently, it has been used to evaluate primary HPV screening in both unvaccinated women and cohorts offered vaccination in England [9 ] and in Australia [10 ]; the Australian findings have underpinned the recent recommendations to transition to primary HPV screening in that country.