We collected the first routine blood results, VitB12-related indicators, and cerebrospinal fluid (CSF) results of the included individuals after admission. Due to the possibility that VitB12 supplements could affect routine blood results and VitB12-related indicators, we classified blood results based on whether the individual had VitB12 supplements before being admitted.
During hospitalization, spinal or head MRI was performed by 1.5T MR devices (Magnetom H-15 and Vision; Siemens, Erlangen, Germany). Depending on the clinical evaluations, the spinal cord segments and the head were scanned with sagittal and axial reconstruction. The scanning sequences included T1-weighted imaging (T1WI), T2-weighted imaging (T2WI), and fluid-attenuated inversion recovery (FLAIR) sequences. T1WI (repetition time/echo time: 500–550/10–15) and T2WI (repetition time/echo time: 3,000–4,000/100–120) were performed with echo train lengths of 5. Other MRI scan parameters included a 3-mm section thickness and a 1-mm scanning interval. The locations and signs of the MRI abnormalities were recorded and collected.
Electromyography (EMG) of the median, ulnar, peroneal, tibial, and sural nerves was available for most of the patients. The compound muscle action potential (CMAP) amplitude, distal latency, conduction velocity, and the amplitude and conduction velocity of the sensory nerve action potential (SNAP) were measured. Based on the EMGs, an experienced neurologist, and an experienced EMG technician further classified the individuals as (1) sensorimotor, motor, or sensory neuropathy; and (2) axonal damage dominant type or demyelination dominant type.
During hospitalization, spinal or head MRI was performed by 1.5T MR devices (Magnetom H-15 and Vision; Siemens, Erlangen, Germany). Depending on the clinical evaluations, the spinal cord segments and the head were scanned with sagittal and axial reconstruction. The scanning sequences included T1-weighted imaging (T1WI), T2-weighted imaging (T2WI), and fluid-attenuated inversion recovery (FLAIR) sequences. T1WI (repetition time/echo time: 500–550/10–15) and T2WI (repetition time/echo time: 3,000–4,000/100–120) were performed with echo train lengths of 5. Other MRI scan parameters included a 3-mm section thickness and a 1-mm scanning interval. The locations and signs of the MRI abnormalities were recorded and collected.
Electromyography (EMG) of the median, ulnar, peroneal, tibial, and sural nerves was available for most of the patients. The compound muscle action potential (CMAP) amplitude, distal latency, conduction velocity, and the amplitude and conduction velocity of the sensory nerve action potential (SNAP) were measured. Based on the EMGs, an experienced neurologist, and an experienced EMG technician further classified the individuals as (1) sensorimotor, motor, or sensory neuropathy; and (2) axonal damage dominant type or demyelination dominant type.
Free full text: Click here
