Transcriptional Profiles of Allergic Rhinitis

GSE43523 (https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE43523), a dataset derived from nasal epithelial cells, and GSE75011 (https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE75011), a dataset derived from Th2-enriched CD4+ T cells from peripheral blood, were obtained from the GEO database. GSE43523, which includes seven samples from patients with seasonal AR (SAR) and five samples from non‑allergic healthy controls, was derived from the GPL6883 platform (Illumina HumanRef-8 v3.0 expression bead chip), and GSE75011, which includes 25 samples from patients with AR and 15 samples from healthy controls, was derived from the GPL16791 platform (Illumina HiSeq 2500) [11 (link)]. The flow chart of our study is shown in Additional file 1: Figure S1.

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Hao Y., Wang B., Zhao J., Wang P., Zhao Y., Wang X., Zhao Y, & Zhang L. (2022). Identification of gene biomarkers with expression profiles in patients with allergic rhinitis. Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology, 18, 20.

Publication 2022

HumanRef-8 v3.0 expression bead chip HiSeq 2500

Blood Cd4 t cells Chip Epithelial cells Nasal Patients

Corresponding Organization :

Other organizations : Beijing Tongren Hospital, Capital Medical University

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Variable analysis

independent variables

Seasonal allergic rhinitis (SAR)
Healthy controls

dependent variables

Gene expression in nasal epithelial cells
Gene expression in Th2-enriched CD4+ T cells from peripheral blood

control variables

Non-allergic healthy controls

controls

Positive control: Samples from patients with seasonal allergic rhinitis (SAR)
Negative control: Samples from non-allergic healthy controls

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