3-Amino-quinazolinone derivatives were prepared according to the procedures shown in Scheme 1 (18 ). Then quinazoline derivatives were treated with chloroacetyl chloride in the presence of dichloromethane/triethylamine to afford the 2-chloro -N-(4-oxo-2-quinazolin3 (3H)-yl) acetamide derivatives. Final products were synthesized by the reaction of 2-chloro -N-(4-oxo-2-quinazolin3 (3H)-yl) acetamide derivatives with 4-mehyl-4-H-1, 2, 4-triazole- 3-thiol in dry acetone and potassium carbonate (19 20 ).
Protocol detail
Synthesis of 3-Amino-quinazolinone Derivatives
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Acetamide
Acetone
Chloroacetyl chloride
Derivatives
Dichloromethane
Potassium carbonate
Quinazoline
Quinazolinone
Thiol
Triazole
Triethylamine
Corresponding Organization :
Other organizations : Isfahan University of Medical Sciences
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Variable analysis
independent variables
- Treatment of quinazoline derivatives with chloroacetyl chloride in the presence of dichloromethane/triethylamine
- Reaction of 2-chloro-N-(4-oxo-2-quinazolin3 (3H)-yl) acetamide derivatives with 4-mehyl-4-H-1, 2, 4-triazole- 3-thiol in dry acetone and potassium carbonate
- Synthesis of 2-chloro-N-(4-oxo-2-quinazolin3 (3H)-yl) acetamide derivatives
- Synthesis of final products
- Dichloromethane
- Triethylamine
- Dry acetone
- Potassium carbonate
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