In each experimental session, subjects were asked to describe the experiences of drug induced ASC by the German versions of the OAV or 5D-ASC questionnaires. The OAV was used in studies conducted before the year 2000 (n = 27), while the 5D-ASC was used in all later studies (n = 16). Because the 5D-ASC is an extension of the OAV, all 66 OAV items are also fully contained in the 5D-ASC. They also appear in the same order in both questionnaires, but are interspersed by 5D-ASC unique items when presented to the subjects as part of the 5D-ASC. Because the available samples would have been too small to investigate the factorial structures of both questionnaires, items from the 5D-ASC data were combined with the corresponding items of the OAV in the present study. Each OAV item contains a statement describing a specific experience of ASC in the past tense (eg, “It seemed to me that my environment and I were one”). Subjects were instructed to respond to the described experiences by placing marks on horizontal visual analogue scales (VAS) of 100 millimeters length. The VAS of the OAV are anchored as no, not more than usual on the left and as yes, very much more than usual on the right. The items are scored by measuring the millimeters from the low end of the scale to the subject's mark (integers from 0–100). Because the low end of the scale indicates a neutral response, the response format of these items can be considered as strictly unipolar according to the response format typology of Russel and Carroll [45] (link).
In most studies, the OAV and 5D-ASC were completed during or shortly after the drug effects peaked. However, in some studies, these rating scales were completed after the drug effects had worn off or at multiple time points. In the latter case, we only included those measures that were obtained during the peak drug effect. Depending on the study, the pooled OAV and 5D-ASC questionnaires were completed 60–300 min after psilocybin, 25–120 min after ketamine, and 70–160 min after MDMA administration. Subjects were instructed to retrospectively rate their whole experience from the moment of drug intake to the respective measuring time point.
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