Inclusion criteria were the following: (1) those who met the diagnostic criteria related to Raynaud’s disease11 (link); (2) did not obtain significant improvement after conservative measures, drugs, and acupuncture treatment, or could not tolerate adverse drug reactions; (3) those who were able to actively cooperate to complete treatment, review and follow up.
Exclusion criteria were: (1) diagnosis of combined hypothyroidism, anemia, diabetic peripheral neuropathy, peripheral arteriosclerosis, or hypothalamic dysfunction; (2) lack of effective contact information to achieve follow-up; (3) refusal to participate in follow-up or withdrawal from the study.
This study was approved by the Ethics Committee of the First Affiliated Hospital of Jiaxing University, located in Jiaxing City, Zhejiang Province, China.